Rema Raman Selected Research

N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamide

10/2016	Changes in Neuropsychiatric Inventory Associated with Semagacestat Treatment of Alzheimer's Disease.
1/2015	Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer's disease.
7/2013	A phase 3 trial of semagacestat for treatment of Alzheimer's disease.
8/2008	Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease.

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Rema Raman Research Topics

Disease

33	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 02/2005
19	Stroke (Strokes) 12/2016 - 12/2006
14	Cognitive Dysfunction 01/2022 - 01/2009
13	Ischemic Stroke 12/2016 - 01/2009
7	Dementia (Dementias) 01/2021 - 11/2005
3	Infections 11/2017 - 07/2013
3	Traumatic Brain Injuries (Traumatic Brain Injury) 04/2016 - 01/2014
3	Cerebral Hemorrhage 11/2015 - 01/2009
3	Body Weight (Weight, Body) 03/2014 - 08/2011
2	Tauopathies 01/2022 - 10/2019
2	Seizures (Absence Seizure) 01/2020 - 03/2012
2	Diarrhea 10/2019 - 08/2011
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 08/2017 - 04/2016
2	Heart Arrest (Cardiac Arrest) 12/2016 - 12/2010
2	Disease Progression 01/2015 - 08/2011
2	Hemorrhage 03/2014 - 01/2014
2	Pneumonia (Pneumonitis) 01/2014 - 03/2013
2	Transient Ischemic Attack 08/2012 - 01/2009
2	Psychotic Disorders (Schizoaffective Disorder) 08/2011 - 04/2007
2	Hypothermia 12/2010 - 10/2010
1	Inflammation (Inflammations) 01/2022
1	Neuroinflammatory Diseases 01/2022
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 10/2019
1	Depressive Disorder (Melancholia) 08/2017
1	Brain Edema (Cerebral Edema) 05/2017
1	Chills 05/2017
1	Respiratory Tract Infections (Respiratory Tract Infection) 05/2017
1	Hypoxia (Hypoxemia) 12/2016
1	Ischemia 12/2016
1	Neurobehavioral Manifestations 04/2016
1	Post-Concussion Syndrome 04/2016
1	Surgical Wound Infection 03/2014
1	Neoplasms (Cancer) 03/2014
1	Weight Loss (Weight Reduction) 03/2014
1	Gliosis 01/2014
1	Edema (Dropsy) 01/2014
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2014
1	Obesity 01/2014
1	Weight Gain 01/2014
1	Out-of-Hospital Cardiac Arrest 01/2014
1	Skin Neoplasms (Skin Cancer) 07/2013
1	Tremor (Tremors) 08/2011
1	Sleepiness 08/2011

Drug/Important Bio-Agent (IBA)

15	Tissue Plasminogen Activator (Alteplase)FDA Link 12/2016 - 12/2006
13	Amyloid (Amyloid Fibrils)IBA 01/2022 - 07/2013
8	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2009
5	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2021 - 08/2008
4	Apolipoproteins E (ApoE)IBA 01/2021 - 09/2010
4	N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA 10/2016 - 08/2008
4	Amyloid beta-PeptidesIBA 01/2014 - 02/2005
3	Vitamin E FDA LinkGeneric 09/2010 - 01/2009
2	Insulin (Novolin)FDA Link 01/2022 - 01/2020
2	A-factor (Streptomyces)IBA 01/2021 - 11/2017
2	atabecestatIBA 01/2021 - 11/2019
2	Proteins (Proteins, Gene)FDA Link 07/2013 - 02/2005
2	Valproic Acid (Depakote)FDA LinkGeneric 08/2011 - 11/2005
2	Donepezil (Aricept)FDA LinkGeneric 07/2009 - 01/2009
1	4- (N- methylamino)- 4'- (2- (2- (2- fluoroethoxy)ethoxy)ethoxy)stilbeneIBA 01/2022
1	florbetapirIBA 01/2022
1	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2022
1	Phenytoin (Dilantin)FDA LinkGeneric 01/2020
1	Levetiracetam (Keppra)FDA LinkGeneric 01/2020
1	Phenobarbital (Luminal)FDA Link 01/2020
1	Phosphotransferases (Kinase)IBA 10/2019
1	Prion ProteinsIBA 10/2019
1	saracatinibIBA 10/2019
1	Peptides (Polypeptides)IBA 10/2019
1	NeurosteroidsIBA 08/2017
1	ganaxoloneIBA 08/2017
1	Pregnanolone (Allopregnanolone)IBA 08/2017
1	Intravenous Immunoglobulins (IVIG)FDA Link 05/2017
1	Neuroprotective AgentsIBA 12/2016
1	Galantamine (Galanthamine)FDA LinkGeneric 04/2016
1	Methylphenidate (Ritalin)FDA LinkGeneric 04/2016
1	ResveratrolIBA 10/2015
1	solanezumabIBA 01/2014
1	ElementsIBA 01/2014
1	VaccinesIBA 01/2014
1	Antihypertensive Agents (Antihypertensives)IBA 11/2013
1	Meperidine (Pethidine)FDA LinkGeneric 03/2013
1	Antipsychotic Agents (Antipsychotics)IBA 03/2012
1	Glucose (Dextrose)FDA LinkGeneric 01/2012
1	NitrogenIBA 12/2010
1	Therapeutic UsesIBA 12/2010
1	CreatinineIBA 12/2010
1	Urea (Carbamide)FDA LinkGeneric 12/2010
1	Docosahexaenoic AcidsIBA 11/2010

Therapy/Procedure

11	Activities of Daily Living (ADL) 01/2020 - 08/2008
5	Therapeutics 01/2020 - 01/2012
4	Induced Hypothermia 12/2016 - 10/2010
3	Thrombolytic Therapy 11/2015 - 11/2010
3	Contraindications 06/2015 - 11/2012
2	Aftercare (After-Treatment) 08/2017 - 08/2010
2	Arthroplasty 03/2014 - 01/2014
1	Secondary Prevention 01/2020
1	Counterpulsation (External Counterpulsation) 11/2015
1	Knee Replacement Arthroplasty (Total Knee Replacement) 03/2014
1	Hip Replacement Arthroplasty (Total Hip Replacement) 03/2014
1	Catheters 01/2014
1	General Anesthesia 12/2010